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(29 July 2003) Aabel is a new, and recently updated high performance data management, processing, & charting application for Mac OS X (26 Jan 2004) Abinit is a package to allow the calculation of the total energy, charge density and electronic structure of systems. (29 August 2005) ADF2005: has been updated bySCM, the OS X port of its quantum chemistry software is the first time ADF has been made available on the Mac platform. The release means chemists can now perform complex quantum chemical calculations using Density Functional Theory (DFT) (13 Oct 2004) AMBER Instructions for getting AMBER to run under MacOSX and on a G5 cluster (29 July 2003) AstexViewerA Java molecular graphics program that assists in structure based drug design. It can be used as an Applet in a web page with web page controls and as a desktop application. Atom in a Box Real time Visualization of Quantum Atomic Orbitals Atomic Mac A periodic table of elements Alienorb If you need any help with porting code to take advantage Altivec this site is a great resource. (13 Oct 2004) ALOGPS now runs under MacOSX, This program predicts lipophilicity and aqueous solubility of chemical compounds (13 Oct 2004) AutoDock is a suite of automated docking tools. It is designed to predict how small molecules, such as substrates or drug candidates, bind to a receptor of known 3D structure, this now includes the graphical front-end of AutoDock and AutoGrid, AutoDockTools, for Mac OS X Biotechnix 3D is a complete bioinfomatics solution for molecular biologists, including DNA and protein sequence analysis and protein structure 3D viewing (13 Oct 2005)BioXtakes advantage of the Unix underpinnings of Mac OS X by using command line sequence analysis tools from the ebiotools package (which contains software from the EMBOSS project, among others). By presenting these Unix tools in the form of a Mac application, BioX leverages the best of both worlds (13 Feb 2005)biOpen a new and unique sequence analysis and structure visualization software based on a plugin architecture.that allows dynamic integration of analysis tools in the software's core. BLAST Thisversion has been optimised by Apple to afford a considerable speed improvement BLAST NCBI Sequence alignment tool designed to support analysis of nucleotide and protein from:William Van Etten BLAST Washington University Sequence alignment tool, free to academic and non-commercial users (8 Apr 2003) CACTVS cheminfomatics system for computational chemistry is in beta test. (19 March 2005) CAChe is molecular modelling software that aids researchers in studying and modeling structures and reactions. CAChe allows visualization of molecules in 3D, searching for conformations, analyzing chemical reactivity and predicting properties of compounds on desktop computer. CCP4 The CCP4 program suite is a collection of disparate programs covering most of the computations required for macromolecular crystallography. They have been collected and developed under the auspices of the Collaborative Computing Project Number 4, in Protein Crystallography, supported by the UK Science and Engineering Research Council (serc) since 1979 and currently the Biotechnology and Biological Sciences Research Council (bbsrc), and coordinated at Daresbury Laboratory. An excellent description of how to install together with a great selection of crystallography tools is available from the W.G.Scott research group here Also look at AMIGOS, Curves, Eden, Freehelix, Solve/resolve and Torsions available from Luca Jovine (11 Feb 2003) The Chemistry Development Kit (CDK) The CDK classes are Java utitility classes for ChemoInformatics and Computational chemistry, written in Java (8 Apr 2003) Ch is a superset of C/C++ interpreter for cross platform numerical computing and 2D/3D plotting (18 Jan 2005) Checkmol can be compiled under MacOSX using Free Pascal to compile just type:- fpc checkmol.pas -S2 -Tdarwin. Checkmol is a command-line utility program which reads molecular structure files in different formats and analyzes the input molecule for the presence of various functional groups and structural elements. At present, approx. 200 different functional groups are recognized. Output can be either clear text, a bitstring or its ASCII representation, or a set of special 8-character codes. This output can be easily placed into a database table, permitting the creation of chemical databases with a functional group search option. (19 March 2005) Chem-4D a chemistry drawing package written in Java. (2 Nov 2003) Chemaxon have updated a number of their Java applications including Marvin ; a collection of Java tools for drawing and displaying chemical structures, substructures and reactions and includes plug-ins to predict physico-chemical characteristics such as pKa, logP and logD. JChem Base ; a Java tool for the development of applications that allow for the search of mixed chemical structure and non-structural data and can integrate a variety of database systems (Oracle, SQL, Access, etc) with web interfaces. JChem Base also integrates ChemAxon's other drug discovery tools. Standardizer ; structure canonization tool converting molecules from different formats into standard representation. Screen ; screening based on pharmacophore or chemical fingerprints or other descriptors. Reactor ; generating reaction products from reaction equations and reactants. JChem Cartridge for Oracle; Access many JChem functions, such as structure searching or property predictions, from within Oracle's SQL. Fragmenter ; generating building blocks based on Recap rules from molecule libraries. JKlustor ; clustering and diversity calculations based on molecular fingerprints or other properties. (25 Aug 2005) Chemical development kit (CDK) a set of java classes for building cheminformatics applications (7 Nov 2005) Model ChemLab is a unique product incorporating both an interactive simulation and a lab notebook workspace with separate areas for theory, procedures and student observations. Commonly used lab equipment and procedures are used to simulate the steps involved in performing an experiment. Users step-through the actual lab procedure while interacting with animated equipment in a way that is similar to the real lab experience (1 June 2006) ChemSpotlight is a Spotlight metadata importer plugin for Mac OS X 10.4 Tiger, which reads common chemical file formats (MDL .mol, .mdl, .sd, .sdf, Tripos .mol2, Protein Data Bank .pdb, Chemical Markup Language .cml, and XYZ) using the Open Babel chemistry library. It is provided as a Universal Binary for PowerPC and Intel, for optimized performance on both. ChemSpotlight indexes chemistry files, adds molecular formulas (complete with subscripts in the Finder), molecular weight, and a variety of other information for Spotlight searches and ÒGet InfoÓ windows (13 Oct 2004) ChemTree is now available for MacOSX it is a statistical analysis software based on recursive partitioning, that facilitates intelligent, target specific compound selection for High Throughput Screening (HTS). The software takes the compound structures and results from a screen, generates a model that predicts the results based on molecular features, and applies that model to untested compounds (25 May 2003) UCSF Chimera is a highly extensible, interactive molecular graphics program is available for MacOSX, both X-windows and native versions are available. (19 March 2005) CONFLEX Corporation develops and licenses the CONFLEX5™ and PARALLEL CONFLEX software packages for fast, accurate molecular conformational analysis and searching. ConvertTable Units ConverTable Units accepts "unit conversion plug-in" files, so it's extensible and can handle far more than the hundreds of possible conversions already built-in ChemBuddy a chemical analysis and stoichiometryprogram Chemdraw The best chemistry drawing package is now available for MacOSX available from Cambridgesoft. They also supply browser plugins that allow almost all the desktop functionality to be accessed from within a web browser. (17 Feb 2003) ChemKey is a desktop chemistry refererence database containing over 90,000 records collected over 40 years covering all aspects of chemistry. (23 Apr 2003) The Chemical Thesaurus from meta-synthesis is a great collection of free chemical information, slides and gadgets COLUMBUS Ron Shepard has ported the COLUMBUS Program System to MacOSX. These programs perform molecular electronic structure calculations including geometry optimizations and property calculations. (13 Oct 2004) CN3D Cn3D is a helper application for your web browser that allows you to view 3-dimensional structures from NCBI's Entrez retrieval service. Cn3D runs on Windows, Macintosh, and Unix. CNS A crystallographic and NMR system. An excellent description of how to install is available here (1 Jan 2006) CrystalDiffract X and CrystalMaker and Single Crystal for fully-interactive visualization and analysis of crystal and molecular structures and simulation x-ray & neutron patterns from CrystalMaker files (16 Dec 2005) Dalton is a powerful molecular electronic structure program, with an extensive functional for the calculation of molecular properties at the HF, DFT, MCSCF, and CC levels of theory. (25 Aug 200) The MacOSX version of Datadesk has been updated (18 Jan 2003) Daylight The Daylight toolkit and high performance cheminformatics database have been ported to MacOSX and is now available in the latest distribution as a beta test. If you are interested I suggest you contact Peter Nielsen (peter@daylight.com). (17 May 2004)DINO is a realtime 3D visualization program for structural biology data. It runs under X-Windows and uses OpenGL (4 Jan 2006) Fully Tiger compatible, DiscoveryGate from MDL offers scientists broader access to a structure-searchable online platform for integrated researching of databases, journal articles, patent publications and reference works (1 Feb 2005) EasyChem is designed to draw chemical molecules in an intuitive way, with a very high quality (designed for book-publishing). Eden is an implementation of the holographic method to recover the electron density distribution of molecules within a crystal. EMBOSS theEuropean Molecular Biology Open Software Suite is a package of high-quality FREE Open Source software for sequence analysis. (9 Dec 2005) EMAN is a software to reconstruct 3D images from EM-pics. There are also a number of other structural biology applications available here (19 Oct 2005) Evince newly developed java based platform for advanced data analysis. The software can be used for design of compound libraries and contains a combination of multivariate statistical algorithms such as PCA and PLS and interactive visualisations. For example can data be imported in .sdf format and molecule structures shown in 3D together with results from multivariate modelling. (25 Aug 2005) Folding at Home client for simulating protein folding Garlic A 3D molecular visulisation programme created by Damir Zucic. This was my first port, it requires X-Tools from Tenon. Minor modifications of the Makefile (highlighted in red below) allow compilation. The source code is available here CC = gcc CCOPT = -O -I/usr/X11R6/include #CCOPT = -O3 #CCOPT = -ansi -pedantic -O -Wall -Wstrict-prototypes -g3 HEADERS = defines.h typedefs.h LIBPATH = -L/usr/X11R6/lib LINKOPT = -lX11 -lm (25 May 2003)Gaussian 03M is a complete implementation of the popular Gaussian electronic structure modeling program for the Mac OS X environment. Also GaussView a full featured graphical user interface is now available for MacOSX. (25 August 2005) Ghemical is a computational chemistry software package (2 Oct 2002) Gifa Version 5 is a sophisticated computer program designed for the processing, the visualization and the analysis of 1D and 2D NMR data-set. GROMACS is a versatile package to perform molecular dynamics, i.e. simulate the Newtonian equations of motion for systems with hundreds to millions of particles. See also Tips to compile gromacs on MacOSX (19 March 2005) HKL-2000, a new program package based on the original HKL Suite, is the premier software of choice for structural biology. Analysis of the Protein Data Bank (PDB) shows that nearly 80% of all entries were processed with the HKL/HKL-2000 package and it is now available for MacOSX. (19 March 2005) HyperChem is now available for MacOSX, OpenGL graphics for sophisticated rendering of molecules and properties, Full range of molecular mechanics and quantum mechanics methods., Protein and DNA capabilities for modeling and manipulation with PDB files. Scripting capabilities to automate and your molecular modeling workflow.Molecular dynamics, Langevin dynamics and Monte Carlo statistical mechanics. Spectral computations including vibrational analysis and excited electronic states. (5 June 2006) iBabel 2.0 is an AppleScript Studio application that provides a graphical interface for the command line-driven file conversion application OpenBabel. The update requires the installation of OpenBabel 2.0, and includes additional file conversions as well as very fast similarity and sub-structure based searching. Structures can be viewed in 2D or 3D as appropriate using the embedded Jmol or JChempaint applets. Now uses ChemSpotlight to search chemical content on your hard drive (Updated 1 June 2006) iChem written in Cocoa for Mac OS X exclusively, iChem is a full-featured periodic table and molecular weight calculator. (2 Nov 2003) ICM-Browser, a new product in the ICM family from Molsoft, provides a biologist or a chemist with direct access to the treasures of structural biology and protein families. It reads PDB files or alignment files directly from the database web-sites and provides rich professional molecular graphics environment with powerful representations of proteins, DNA and RNA, and multiple sequence alignment IGOR Pro is an interactive environment for experimentation with scientific and engineering data and for the production of publication-quality graphs and page layouts iMass a molecular mass calculator, a periodic table of the elements, an isotope distribution graph and a calculator that computes elemental compositions matching a given mass. iMass understands complex chemical formulas as well as user defined abbreviations for commonly used formulas. iMol is a free molecular visualisation program written in Object C and using OpenGL for the graphics so no need for X-windows, the author Piotr Rotkiewicz is looking for feedback. (5 Jan 2006) InforSense KDE is an Integrative Analytics platform for improved decision-making across life sciences research. BioSense Grid adds a service-based high-performance environment for creating bioinformatics applications (16 Jan 2005) iNMR Mestrelab Research is very proud to distribute this fantastic tool for the processing and analysis of NMR data in a Mac environment. iNMR is still in development, but is already a working program with great functionality. For more information, visit the iNMR web site. NMRDev should also be released soon. (10 Feb 2005) JChem Modules: JChem Base (chemical database searching and database integration), JChem Cartridge for Oracle, Standardizer (structure canonization), Screen (virtual screening), Reactor (reaction modeling), Fragmenter (generating building blocks), JKlustor (clustering and diversity calculations), Chemical Term Evaluator Jmol is a Java molecular viewer for three-dimensional chemical structures. Features include reading a variety of file types and output from quantum chemistry programs, and animation of multi-frame files and computed normal modes from quantum programs. Also available as an applet. Jmol is a fully compatible replacement for rasmol/chime in that it will use rasmol/chime scripts jVisualiser for analysing and visulising fisrt-order NMR coupling patterns (25 Aug 2005) Kinemage have a variety of very useful bits of software for investigating protein structure Mage a 3D display program, KiNG, Rduce, Probe, Dang KnowledgeMiner A self-organising data mining tool (29 May 2003) MacElementos a localised Spanish free periodic table of elements MacChess A macromolecular crystallographic facility MacGAMESS is a fully functional sequential implementation of GAMESS running native on the PowerMacintosh, you may also want to get MacMolPlt an excellent tool for viewing GAMESS results. (10 Jan 2005)Marvin is a java application/applet recently updated, for displaying and editing chemical structures, it can be used to render different structure formats including SMILES/SMARTS and MOL files, it can also be used as a drawing package to generate a variety of file formats. (17 Feb 2006)Mathematica 5.2 Now available for MacOSX. Also check out gridMathematica and Mathematica for students. Now gridMathematica 2 delivers a parallel Mathematica environment that’s optimized for modern multiprocessor machines and computational clusters. Also now available as a Univesral Binary The supercomputing speed of Apple's Power Mac G5 provides an incredible environment for scientific computing, and with Mac OS X's unparalleled performance and ease of use, it's only going to get better," said Clent Richardson, Apple's vice president of Worldwide Developer Relations."Mathematica is the most powerful software for doing calculations in science, engineering, and mathematics, and we're thrilled to see Wolfram take advantage of the incredible technologies Mac OS X has to offer. (6 Dec 2005) Mercury updated to version 1.4.1 is now available for MacOSX from CCDC. Mercury offers a comprehensive range of tools for structure visualisation and the exploration of crystal packing (20 June 2004) Chemical Computing Group have released MOE for MacOSX. The Molecular Operating Enviroment is a comprhensive piece of software providing extensible tools for molecualr modelling, bioinformatics, computer aided molecular design all built using Scientific Vector Language (SVL). This programming language allows the rapid construction of novel tools many examples of which are available via SVL exchange. (15 Nov 2002) Edusoft have a number of MacOSX applications including Molconn (15 Jan 2006) MOLCASis a quantum chemistry software developed by scientists to be used by scientists. It is not primarily a commercial product and it is not sold in order to produce a fortune for its owner (the Lund University). The authors have tried in MOLCAS to assemble their collected experience and knowledge in computational quantum chemistry. MOLCAS is a research product and it is used as a platform by the Lund quantum chemistry group in their work to develop new and better computational tools in quantum chemistry. MODELLER is used for homology or comparative modeling of protein three-dimensional structures. The user provides an alignment of a sequence to be modeled with known related structures and MODELLER automatically calculates a model containing all non-hydrogen atoms. MODELLER implements comparative protein structure modeling by satisfaction of spatial restraints and can perform many additional tasks, including de novo modeling of oligopeptides, optimization of various models of protein structure with respect to a flexibly defined objective function, multiple alignment of protein sequences and/or structures, clustering, searching of sequence databases, comparison of protein structures, etc. (22 Oct 2005) MoFa is a program for finding frequent, discriminative molecular substructures in a set of molecules. The name MoFa is an acronym for Molecular Fragment Miner MOLDEN is a package for displaying molecular density.  It is tuned to the Ab Initio packages GAMESS* and GAUSSIAN (17 May 2004)Molinspiration Molinspiration specializes in the development of cheminformatics software in Java. Molinspiration tools are therefore platform independent and may be run on any PC, Mac, UNIX or LINUX machine. The software is distributed in a form of toolkits, which may be used as stand-alone computational engines, used to power web-based tools, or easily incorporated into larger in-house Java applications MOLMOL A molecule viewer ported to Darwin MolMol I've ported MolMol to MacOSX, this requires X-Tools from Tenon. You can download the makefile from here, you also need to add this header file to this folder molmol/tools/include. The source code is available from here (13 Oct 2004) MolView X is the OSX version of MolView FONT FACE="Helvetica">(5 Oct 2005) MOLWORKS a platform for chemical information software written in Java MOSFLM for processing image plate and CCD data. An excellent description of how to install is available here (1 Feb 2005) MPQC is the Massively Parallel Quantum Chemistry Program. It computes properties of atoms and molecules from first principles using the time independent Schrödinger equation. It runs on a wide range of architectures ranging from individual workstations to symmetric multiprocessors to massively parallel computers. Its design is object oriented, using the C++ programming language and has been ported to G5/MacOSX. NAMD is a parallel, object-oriented molecular dynamics code designed for high-performance simulation of large biomolecular system (17 Feb 2006)NMRtec NMRnotebookTM, is a new NMR software package for processing, analysing and managing NMR data. (17 Nov 2005)NWChem is a computational chemistry package that is designed to run on high-performance parallel supercomputers as well as conventional workstation clusters. It aims to be scalable both in its ability to treat large problems efficiently, and in its usage of available parallel computing resources. NWChem has been developed by the Molecular Sciences Software group of the Environmental Molecular Sciences Laboratory (EMSL) at the Pacific Northwest National Laboratory (PNNL). NMRPipe provides comprehensive facilities for Fourier processing of spectra in one to four dimensions, as well as a variety of facilities for spectral display and analysis. It is currently used in over 300 academic and commercial laboratories. (25 Oct 2004)NMRView softtware foe the visualisation and anlysis of NMR data. (17 May 2002)Numerical tools binaries, source and installation instructions for Fortran, MPL, Octave, Cactus, Globus, TINKER and more. (29 Oct 2004)nuccyl is a Perl program that allows PyMOL, a powerful open-source molecular modeling system, to display atomic models of nucleic acids in a highly simplified representation O is a macromolecular crystallographic modeling tool. It can be used to build, modify and analyze macromolecular structures, there is also a unix beginners installation guide here OpenBabel is a free, open-source version of the Babel chemistry file translation program, Open Babel includes two components, a command-line utility and a C++ library. A MacOSX GUI is also available on the applescripts link at the top of the page. (8 Apr 2003) All the Openeye software is available for MacOSX this includes OMEGA a rapid conformer generator FRED for docking ZAP for electrostatics ROCS shape mapping, the SHAPE toolkit, FILTER a graph based filtering tool,VIDA a compound browser and GUI tool, and OEChem a object oriented programing toolkit for chemistry, new update. OrobosX An X-windows manager that has the look of MacOSX OpenDX is a uniquely powerful, full-featured open source software package for the visualization of scientific, engineering and analytical data. Downloadable binaries are available from VIS Inc. Richard Gillilan has created a series of chemistry extensions. Partek A leading provider of pattern recognition software, data mining and interactive visulaisation tools plan to support Mac OSX. (19 March 2005) PCModel 9 is available for MacOSX, it is designed for research chemists build, minimise and manipulate multiple structures. A variety of forcefields are supported, conformational searching is biult in and there is an interface to Gaussian and Games. They also supply Orbdraw for displaying molecular orbitals and Vibrate for visualise normal vibrational modes. Periodic Table A user configurable Periodic Table (1 Feb 2005) PerlMol is a collection of Perl modules for chemoinformatics and computational chemistry with the philosophy that "simple things should be simple". It should be possible to write one-liners that use this toolkit to do meaningful "molecular munging". The PerlMol toolkit provides objects and methods for representing molecules, atoms, and bonds in Perl; doing substructure matching; and reading and writing files in various formats. (13 Oct 2004) Polyxmass is a collection of programs that integrate into a mass spectrometry data simulation/analysis framework. The molecular objects that are dealt with are polymers. Because the user can define brand new polymers, the program is not targetted at any specific polymer in particular. Indeed, after having defined the basic protein or saccharide chemistry, the user can start using the polyxmass programs on proteinaceous or saccharidic polymer sequences (17 May 2004) PMVA Python based Molecular Viewer (8 Apr 2003) pro Fit An excellent data analysis and graphing package has been updated (11 Feb 2003) Protean helps you predict and display patterns, secondary structural characteristics and physicochemical properties of protein sequences (12 Dec 2002) Protein Dynamics The program simulates the dynamic behavior of proteins, DNA, and RNA, using the AMBER force field. It allows the user to view molecules, create and modify molecules, and run energy minimization and dynamics simulations (6 Nov 2004) Protein Family Alignment Annotation Tool (PFAAT) Pfaat is a Java-based protein sequence alignment application designed to facilitate the analysis, curation, and annotation of large protein sequence families has recently been updated. (28 Feb 2005) PyMOL A 3D molecule viewer, PyMOL is a powerful molecular graphics package for structural biology and other sciences has been optimised for the G5!!. This interactive system is fully scriptable using the Python computing language, and it is free software. Jim Hu has created a MacOSX version of the tutorial originally written by Carly Huitema (16 Dec 2005) QuantumBio provides Pharmaceutical and Biotech companies with fast Quantum Mechanical (QM) solutions for Lead Optimization (17 Nov 2005) Q-Chem the latest version of a modern ab initio electronic structure program, is capable of performing first principles calculations on both the ground and excited states of molecules Rasmol A 3D molecule viewer ported to Darwin (link provided by Pradeep Bashya) (11 Feb 2003) Raster3D - Tools for generating high quality raster images of molecules Ribbons A popular molecular graphics program (28 Dec 2005)SciFinder  SciFinder is now MacOSX native!! it is an easy to use desktop research tool that allows you to explore research topics, browse scientific journals, and stay up to date on today's most recent scientific developments. With SciFinder, no special training is needed. You simply point and click to access more than 19 million abstracts and 35 million substances. (6 Nov 2004) SCWRL3.0 is a completely new version of the SCWRL program for prediction of protein side-chain conformations. SCWRL3.0 is based on a new algorithm based on graph theory that solves the combinatorial problem in side-chain prediction more rapidly than any other available program. SCWRL3.0 is more accurate than previous versions of SCWRL, while the new algorithm will allow for development of more sophisticated energy functions and for incorporation of side-chain flexibility around rotameric positions Scilab Scilab is a scientific software package for numerical computations in a user-friendly environment ScilPySciPy is an open source library of scientific tools for Python. SciPy supplements the popular Numeric module, gathering a variety of high level science and engineering modules together as a single package. SciPy includes modules for graphics and plotting, optimization, integration, special functions, signal and image processing, genetic algorithms, ODE solvers, and other Instructions on building SciPy for the Mac OSX platform, (19 March 2005) SemiChem report that the semiempirical quantum mechanical program Ampac and advanced, fully featured quantitative structure/activity relationship (QSAR) program Codessa are available for MacOSX Smell-o-mints is a Periodic table of the elements for the Macintosh. It's not as full-featured as a lot of other Periodic tables out there, but it's free and looks very nice. Especially if you put it next to the coffee table by the ferns Sparky is a graphical NMR assignment and integration program for proteins, nucleic acids, and other polymers. For more information about what Sparky does look at the introduction in the manual. (12 Feb 2004) Spartan 04 is now availoable for MacOSX. Wavefunction is pleased to announce the release of the first version of Spartan for Macintosh running under OS X optimised for the G4 and G5. This new version will take full advantage of OS X features such as fully preemptive multi-tasking, hardware accelerated open GL graphics, and a multi-button mouse. Through Wavefunction's collaboration with Q-Chem, this new version also includes anentirely new set of computational engines offering a host of powerfulmethods not available in previous Macintosh releases.New Features to Spartan '04 (over Spartan '02): Graphical User Interface, infrared (IR) spectra plots from calculated IR data, 13C-NMR plots from Hartree-Fock molecular orbital theory, UV/vis spectrum plots from Hartree-Fock and CIS or DFT and TDDFT, Spartan Molecular Database: direct and substructure searching, Display hydrogen bonds, Automatic on-screen centering of molecules, Inversion of chiral centers, Help functions available in individual dialogues, Import/Export of SDF, TGF and SKC files (2D) SQLGrinder If you need a tool to access any database that has a JDBC driver (Oracle, Sybase, mySQL, postgresql etc) I highly reccomend this tool, it is a native Cocoa application that has applescript support. Swiss-PdbViewer a carbonised version is available in alpha form (19 Feb 2003) If you are interested in viewing molecular modelling in 3D you will be delighted to hear that Stereographics have announced support for MacOS X, CrystalEyes Workstation for Mac and Monitor ZScreen 2000i for Mac -Here is a Q&A that should answer any questions you may have system compatibility. TINKER a molecular modeling software is a complete and general package for molecular mechanics and dynamics, with some special features for polypeptides. TINKER has the ability to use any of several common parameter sets, such as AMBER-95, CHARMM22, MM2(1991), MM3(2000), OPLS-AA and OPLS-UA (1 Feb 2005) Viewmol is a graphical front end for computational chemistry programs. It is able to graphically aid in the generation of molecular structures for computations and to visualize their results (14 Feb 2005) VMD 1.8.3 VMD is a molecular visualization program for displaying, animating, and analyzing large biomolecular systems using 3-D graphics and built-in scripting. VMD supports computers running MacOS-X,and now uses native windowing and hardware acceleration. The vmd-xplor package is a combination of VMD with the xplor structure determination package (23 Apr 2003) VVI has released Vvidget User a unique drawing application which gives you the freedom to layout graph-based figures the way you want them and an Interface Builder palette so you can add basic chart types to your custom applications within minutes. Also the DAQ Plot application is the quickest and easiest way to view data from sensors and laboratory equipment with voltage connectors. (23 July 2003) German instructions on porting the chemical drawing package xdrawchem can be found at here . It is also available from fink. XFree86 Allows you to run X-windows applications under MacOSX (28 Sept 2003)X-score is a scoring function that computes the binding affinities of ligands to a target protein (Dr. Xueliang Fang and Dr. Renxiao Wang J. Med. Chem. 2003, 46 2287) whilst it was written for SGI it compiles fine with either Apples GCC or the IBM c++ compiler,

If you want to search for MacOSX applications try here, Versiontracker or here http://osx.hyperjeff.net/Apps/ search engines for Macintosh Applications